Gonadorelin Acetate
Gonadorelin Acetate (GnRH)
CAS: 71447-49-9
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH) — the hypothalamic decapeptide controlling LH and FSH release from the pituitary. Used in HPG axis research and studied for HPTA recovery following suppressive agents. 99.0% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
GnRH receptor agonism on anterior pituitary gonadotrophs triggers LH and FSH secretion. Pulsatile administration restores LH/FSH pulsatility and downstream testosterone/estrogen production. Continuous administration desensitizes receptors (basis for GnRH agonist suppression).
Research FAQ
Why is pulsatile vs continuous delivery important for gonadorelin?
Pulsatile GnRH (every 60-90 min) activates LH/FSH release. Continuous exposure desensitizes GnRH receptors and suppresses LH/FSH — the mechanism used in prostate cancer treatment. Pulse timing is critical to the direction of the hormonal effect.
