PNC-27 30mg
PNC-27
CAS: N/A
PNC-27 is a p53-derived peptide that selectively induces apoptosis in cancer cells by targeting HDM-2 overexpressed on malignant cell membranes. Unlike FOXO4-DRI (senescent cell targeting), PNC-27 targets tumor cells expressing surface HDM-2. Research compound — not for human use. 98.0% HPLC purity.
Specifications
For laboratory research use only. Not for human consumption.
Mechanism of Action
PNC-27 contains the p53 transactivation domain (residues 12-26) fused to a penetratin sequence. Binds HDM-2 on cancer cell surfaces to induce pore formation and selective apoptosis in tumor cells while sparing normal cells with intracellular HDM-2 distribution.
Research FAQ
How does PNC-27 selectivity work?
Cancer cells overexpress HDM-2 on their plasma membrane surface. Normal cells have intracellular HDM-2. PNC-27 only binds surface HDM-2, so it forms pores specifically in tumor cells — the basis for its cancer-selective cytotoxicity in research models.
